A Comparative Study of the Antiproliferative and Apoptotic Effects of Some Chemotherapeutic Drugs on Neuroblastoma Cells

In this study, it was aimed to investigate the antiproliferative and apoptotic effects of nivolumab, cetuximab gemcitabine used in treatment different cancer types as well cisplatin cyclophosphamide neuroblastoma on SH-SY5Y cells. The effect each chemotherapeutic cell viability individual IC50 values were determined by crystal violet method. To determine their effects, RT-PCR Annexin V-FITC apoptosis detection technique used. results indicated that all drugs showed dose-dependent cytotoxic induced cisplatin, cyclophosphamide, cetuximab, calculated 10.91 µM, 0.54 30.26 μM 4.74 0.036 μM, respectively. After dose rates found 21%, 12%, 16%, 10% 39% It statistically significant changes mRNA expression levels almost apoptosis-related genes occurred after treatment. conclusion, more cells than other chemotherapeutics. is clear further studies will elucidate mechanism action may contribute neuroblastoma.